5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
Read More
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
Most Useful Reviews
9
Heart tissue protection
4 people found this helpful
N-acetylcysteine (NAC) is an antioxidant used for respiratory diseases. Acetylcysteine offers various benefits, including antioxidant action, protecting the throat and lungs, improving immunity, and reducing kidney and liver damage. It stabilises blood sugar and helps reduce the risk of heart disease by preventing oxidative damage to heart tissue.
Read More
9
Pressure regulation
NAC may lower the risk of heart disease by reducing cholesterol and blood pressure and improving blood flow. Research indicates that NAC mitigates oxidative stress and prevents metabolic shifts in heart tissue.
Read More
9
Heart health improvement
An indispensable drug, NAC may reduce heart disease risk by lowering cholesterol and blood pressure while improving blood flow. Research shows that it reduces oxidative stress and prevents metabolic shifts in heart tissue.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
Read More
9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart tissue protection
4 people found this helpful
N-acetylcysteine (NAC) is an antioxidant used for respiratory diseases. Acetylcysteine offers various benefits, including antioxidant action, protecting the throat and lungs, improving immunity, and reducing kidney and liver damage. It stabilises blood sugar and helps reduce the risk of heart disease by preventing oxidative damage to heart tissue.
Read More
9
Pressure regulation
NAC may lower the risk of heart disease by reducing cholesterol and blood pressure and improving blood flow. Research indicates that NAC mitigates oxidative stress and prevents metabolic shifts in heart tissue.
Read More
9
Heart health improvement
An indispensable drug, NAC may reduce heart disease risk by lowering cholesterol and blood pressure while improving blood flow. Research shows that it reduces oxidative stress and prevents metabolic shifts in heart tissue.
Read More
6
Supports heart function
I recommend this high-quality combination of two drugs. The first is strong and acts as an antioxidant, enhancing iodine absorption in the body. It protects the thyroid gland from free radical damage, plays a role in activating thyroid hormones, and is beneficial for heart disease and hypertension, especially post-myocardial infarction. The composition's ingredients are of excellent quality, and the capsules are medium in size and easy to swallow.
Read More
6
Risk reduction
Good, a nice supply of NAC. Reducing oxidative stress with antioxidants like NAC can help lower the risk of certain health conditions, such as heart disease, diabetes, and infertility.
Read More
Frequently Asked Questions
9
Pressure regulation
NAC may lower the risk of heart disease by reducing cholesterol and blood pressure and improving blood flow. Research indicates that NAC mitigates oxidative stress and prevents metabolic shifts in heart tissue.
9
Heart health improvement
An indispensable drug, NAC may reduce heart disease risk by lowering cholesterol and blood pressure while improving blood flow. Research shows that it reduces oxidative stress and prevents metabolic shifts in heart tissue.
6
Supports heart function
I recommend this high-quality combination of two drugs. The first is strong and acts as an antioxidant, enhancing iodine absorption in the body. It protects the thyroid gland from free radical damage, plays a role in activating thyroid hormones, and is beneficial for heart disease and hypertension, especially post-myocardial infarction. The composition's ingredients are of excellent quality, and the capsules are medium in size and easy to swallow.
9
Heart tissue protection
4 people found this helpful
N-acetylcysteine (NAC) is an antioxidant used for respiratory diseases. Acetylcysteine offers various benefits, including antioxidant action, protecting the throat and lungs, improving immunity, and reducing kidney and liver damage. It stabilises blood sugar and helps reduce the risk of heart disease by preventing oxidative damage to heart tissue.
6
Detox support
Good, NAC may reduce the impact of toxins on the body by maintaining glutathione levels. Adequate glutathione can prevent oxidative stress and reduce undesirable effects, including heart disease, infertility, and psychiatric disorders.
7.5
Overall health benefits
The quality is excellent, with benefits noted especially for women. My hair condition has improved, and Omega 3 fish oil is crucial for women! The ingredients are great; it reduces cholesterol and inflammation. Highly recommended for those with heart disease, though the taste is bland. Always consult your doctor before use.
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
7
Environmental metals and heart risk
We examined the impact of environmental metallic and metalloid pollutants, such as arsenic and lead, on heart disease and overall mortality by reviewing existing meta-analyses and systematic reviews. Our search included databases like PubMed and Web of Science, identifying various health outcomes associated with these contaminants.
Worryingly, exposure to harmful metals correlated with increased cardiovascular events. However, we found promising indications that zinc and selenium might provide some protective benefits against heart disease and mortality. While the evidence varied in quality, the protective potential of selenium remains a positive takeaway.
Worryingly, exposure to harmful metals correlated with increased cardiovascular events. However, we found promising indications that zinc and selenium might provide some protective benefits against heart disease and mortality. While the evidence varied in quality, the protective potential of selenium remains a positive takeaway.
7
We examined how different metals in the blood relate to heart issues in individuals with coronary artery disease (CAD). Our cross-sectional study included 1,555 CAD patients in Southwest China, where we measured the blood concentrations of 14 metals.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. 10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. 10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. 10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. 10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. 10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. 10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. 10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. 10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. 10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. 10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. 10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. 10.1016/j.redox.2024.103046
